Jill James, PhD Her view with autism is that the transsulfuration pathway is disrupted in autistic children, resulting in these children being deficient in glutathione, as well as vitamins such as vitamin B6 and vitamin B12, and that maternal glutathione deficiency may also be a risk factor for autism. She has also found that administering these compounds as supplements, as well as methylcobalamin and folinic acid, to autistic children can significantly restore their levels of glutathione and cysteine and may therefore be useful in the treatment of autism. she has produced evidence that autistic children also suffer from impaired methylation capacity.